Piracetam

$21.00

-Description-

Piracetam (2-oxo-Pyrrolidine Acetamide) is a water soluble derivative of the neurotransmitter GABA (Gamma Amino Butyric Acid). Chemically it related to the amino acid L-Pyroglutamic Acid (Pyrrolidine Carboxylic acid), which occurs naturally in human cerebrospinal fluid and plays an important role in cognitive functioning.

-History-

Piracetam was first created in Belgium by UCB in the early 1964. In the early 1970’s after several clinical trials to was approved throughout Europe. Currently it sold in over 100 countries outside the US for treating several health conditions under the name Nootropil. In the US it is sold as a dietary supplement.

Piracetam 500 Grams

-Neurochemical Effects-

: Enhances Brain Metabolism

(By increasing glucose utilization, blood & oxygen flow)

[Boosts mental energy & cerebral circulation]

: Increases Cerebral Phospholipids & Cellular Membrane Fluidity

(By interacting with the polar head moieties of the phospholipid bilayer)

[Supports healthy neuronal communication & cellular structure]

: Supports NeuroReceptor Activity

(By amplifying the density of the muscarinic cholinergic [frontal cortex, striatum, & hippocampus], NMDA (N-Methyl-D-Aspartate) [hippocampus], & AMPA (Alpha-amino-3-hydroxy-5-Methyl-4-isoxazole-Propionic Acid) [cerebral cortex] Receptors)

[Strengthens neurotransmitter receptors involved in memory and neuroprotection]

: Enhances Corpus Callosum Activity

(By raising the amplitude of transcallosal evoked potential and transcommissural encoding mechanisms)

[Increases communication between both hemispheres of the brain, which effects speech and creative thinking]

: Stimulates Locus Coeruleus Neural Network

(By increasing the firing rate of noradrenergic neurons)

[Enhances information processing, attention, cortical/behavioral arousal, learning and memory]

: Supports Cardiovascular & Cerebrovascular Health

(By increasing red, white blood cells & platelet deformability, inhibiting thromboxane A2 synthetase or antagonism of thromboxane A2, reducing von Willebrand's factor & fibrinogen levels)

[Supports Healthy Blood Flow & Inhibits Abnormal Platelet Aggregation]

: Decreases EEG complexity

(Increases cooperatively of brain functional processing)

[Positively effects Neuro-Electrical Functioning]

: Has a significant antioxidant effect.

-Overview-

Piracetam positively supports healthy cognitive & cardiovascular functioning by a multifaceted means of action.

-Notes-

Piracetam is highly recommended by many healthcare professionals such as Lee Crost M.D. and health organizations, such as the Life Extension Foundation and American Academy of Antiaging Medicine.

-Dose-

5-10 grams daily.

-When can I feel it?-

Usually works within an hour to a few days. Maximum benefits are seen within a month.

-Research-

Int J Psychophysiol 1999 Oct;34(1):81-7
Single-dose piracetam effects on global complexity measures of human spontaneous multichannel EEG.

Kondakor I, Michel CM, Wackermann J, Koenig T, Tanaka H, Peuvot J, Lehmann D. The KEY Institute for Brain-Mind Research, University Hospital of Psychiatry, Zurich, Switzerland.

The results indicate that a single dose of piracetam dose-dependently affects the spontaneous EEG in normal volunteers, showing effects at the lowest treatment level. The decreased EEG complexity is interpreted as increased cooperativity of brain functional processes.

Psychopharmacology (Berl) 1976 Sep 29;49(3):307-9
Increase in the power of human memory in normal man through the use of drugs.

Dimond SJ, Brouwers EM.

Nootropyl (Piracetam) a drug reported to facilitate learning in animals was tested for its effect on man by administering it to normal volunteers. The subjects were given 3x4 capsules at 400 mg per day, in a double blind study. Each subject learned series of words presented as stimuli upon a memory drum. No effects were observed after 7 days but after 14 days verbal learning had significantly increased.

Acta Psychiatr Scand 1976 Aug;54(2):150-60
Piracetam-induced improvement of mental performance. A controlled study on normally aging individuals.

Mindus P, Cronholm B, Levander SE, Schalling D.

A double-blind, intra-individual cross-over comparison of the mental performance of 18 aging, non-deteriorated individuals during two 4-week periods of piracetam (1-acetamide-2-pyrrolidone) and placebo administration was performed using conventional and computerized perceptual-motor tasks. In a majority of these tasks the subjects did significantly better when on piracetam than on placebo, a finding consistent with ratings completed by two independent observers.