Lithum Orotate

Lithum is a naturally occuring trace mineral with important functions in maintaining healthy cognitive health.

Lithium 8 mg (from Lithium Orotate 100 mg)

-Neurochemical effects-

It protects against stress induced memory loss (1) and has several neuroprotective effects. This neuroprotection is accompanied by an inhibition of NMDA-receptor-mediated calcium influx, upregulation of anti-apoptotic Bcl-2, downregulation of pro-apoptotic p53 and Bax, and activation of cell survival factors.

Lithium supplemention antagonizes glutamate-induced activation of c-Jun-N-terminal kinase (JNK), p38 kinase, and AP-1 binding, which has a major role in cytotoxicity, and suppresses glutamate-induced loss of phosphorylated cAMP responsive element binding protein (CREB).

Lithium also induces the expression of brain-derived neurotrophic factor (BDNF) and subsequent activation TrkB, the receptor for BDNF, in cortical neurons. (2)